To investigate the potentially synergistic effects of saffron and extremely low frequency magnetic fields on gene expression of the vascular endothelial growth factor 2 (VEGFR2) in human breast cancer cells.
The vascular endothelial growth factor 2 is known to be involved in the angiogenesis. A reduced expression of this growth factor could inhibit the angiogenesis in tumors and therefore inhibit the tumor growth.
Human breast cancer cells were subjected to different treatments: 1.) cultivation without treatment (control group), 2.) cultivation in the presence of saffron (100, 200, 400 and 800 µg/ml), 3.) magnetic field exposure and 4.) magnetic field exposure + saffron (100, 200, 400 and 800 µg/ml).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
1 hour
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 1 hour |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 0.04 T | - | - | - | or 0.004 T? (contradictory statements) |
In magnetic field exposed cells as well as in cells cultivated in the presence of saffron, the gene expression level of the vascular endothelial growth factor was significantly decreased in comparison to the control group. A combination (co-exposure) of both treatments led to a further decrease in the expression level, which indicates a synergistic effect. No results are stated regarding cell viability and cell morphology.
The authors conclude that saffron as well as exposure to extremely low frequency magnetic fields could reduce the gene expression level of the vascular endothelial growth factor 2 in human breast cancer cells.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.
