To study the effects of low-intensity extremely high frequency electromagnetic radiation (42.2 GHz) on the fatty acid composition of thymic cells and blood plasma in normal mice and in mice with peritoneal inflammation.
Inflammation was induced by intraperitoneal zymosan injection. Four groups of mice (each group n=2) were used: (1) sham exposure group (injected with physiological saline solution); (2) exposure group (injected with saline solution); (3) sham exposure group (with zymosan-induced peritoneal inflammation); (4) exposure group (with zymosan-induced peritoneal inflammation). The experiments were repeated three times. At 4 h after exposure/sham exposure the mice were decapitated.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
42.2 GHz
Modulation type:
CW
Exposure duration:
continuous for 20 min
|
|
Mice were divided into four groups: i) sham exposure ii) RF exposure iii) induced inflammation + sham exposure iv) induced inflammation + RF exposure
| Frequency | 42.2 GHz |
|---|---|
| Type | |
| Charakteristic | |
| Exposure duration | continuous for 20 min |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 300 mm |
| Setup | animals kept in a 100 mm x 100 mm x 130 mm plastic container; multilayer absorbent placed between the animal container and the floor; antenna's major lobe width = 130 mm at 300 mm distance; exposure from the top |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power | 8 mW | - | measured | - | - |
| power density | 0.1 mW/cm² | - | calculated | - | - |
| SAR | 1.5 W/kg | - | calculated | - | at the container's surface |
The data showed that the exposure of normal mice to low-intensity extremely high frequency electromagnetic radiation significantly increased the content of polyunsaturated fatty acids (eicosapentaenoic acid and docosapentaenoic acid) in thymic cells. Using the inflammation model, it was shown that the exposure of mice significantly increased the content of polyunsaturated fatty acids (dihomo-gamma-linolenic acid, arachidonic acid, eicosapentaenoic, docosapentaenoic, and docosahexaenoic) and reduced the content of monounsaturated fatty acids (palmitoleic acid and oleic acid) in thymic cells.
Changes in the fatty acid composition in the blood plasma were less pronounced and became manifest in an increase in the level of saturated fatty acids during the inflammation.
The authors conclude that the changes of fatty acid composition induced by low-intensity extremely high frequency electromagnetic radiation may be considered as a key element in the mechanisms of biological effects of radiation.
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