To study the effect of low-intensity laser light (He-Ne, 0.2 mW/cm², 632.8 nm, exposure time 1 min) and of superhigh frequency electromagnetic fields (8.15-18 GHz, 1 µW/cm², exposure time 1 h) on phospho-SAPK/JNK production in mouse spleen lymphocytes.
To block intracellular Hsp90 proteins, geldanamycin (1 µg/ml) was used.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
8.15–18 GHz
Exposure duration:
continuous for 1 h
|
|
Cells were treated in three groups: i) exposure to low-intensity laser light ii) exposure to centimeter waves iii) control In a second experiment the same groups were used but cells were pre-incubated with geldanamycin.
| Frequency | 8.15–18 GHz |
|---|---|
| Type | |
| Exposure duration | continuous for 1 h |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 1 µW/cm² | mean | - | - | - |
The data showed a significant increase of phospho-SAPK/JNK production in lymphocytes after exposure to laser light or microwaves in both cell groups (with/without geldanamycin). Exposure to superhigh frequency electromagnetic fields produced a more significant effect (greater increase) compared to the low-intensity laser light exposure.
The authors concluded that activation of the SAPK/JNK signal pathway plays one of the central roles in cellular stress response to low-power non-ionizing radiation.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.
