Study type: Medical/biological study (experimental study)

Effect of continuous-wave and amplitude-modulated 2.45 GHz microwave radiation on the liver and brain aminoacyl-transfer RNA synthetases of in utero exposed mice med./bio.

By: Kubinyi G, Thuroczy G, Bakos J, Boloni E, Sinay H, Szabo LD
Published in: Bioelectromagnetics 1996; 17 (6): 497-503
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Aim of study (acc. to author)

To investigate the effects of continuous-wave (CW) and amplitude-modulated (AM) microwave (MW) exposure on aminoacyl-transfer RNA synthetase.

Background/further details

The enzyme was isolated from liver and brain of in utero exposed mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: AM
Exposure duration: repeated daily exposure, 100 min/day during the 19 day gestation period.
  • SAR: 4.23 mW/g mean (cf. remarks) (+/- 0.63 W/kg)
  • power density: 30 W/m² mean (time averaged in the center of the cage)
Exposure 2: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 100 min/day during the 19 day gestation period.
  • SAR: 4.23 mW/g mean (cf. remarks) (+/- 0.63 W/kg)
  • power density: 30 W/m² mean (time averaged in the center of the cage)

Exposure 1

Main characteristics
Frequency 2.45 GHz
Exposure duration repeated daily exposure, 100 min/day during the 19 day gestation period.
Modulation
Modulation type AM
Modulation frequency 50 Hz
Modulation depth 50 %
Additional info

Rectangular waveform.
Exposure setup
Exposure source
Chamber Anechoic room /2.55 m x 1.8 m x 2.9 m
Setup Animals were kept in round plastic cages (5 cm high, 23 cm diameter)
Additional info Cages were divided into 10 seperate boxes. Control anilmals were placed for the same period in identical cages.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4.23 mW/g mean calculated cf. remarks +/- 0.63 W/kg
power density 30 W/m² mean measured - time averaged in the center of the cage

Exposure 2

Main characteristics
Frequency 2.45 GHz
Exposure duration repeated daily exposure, 100 min/day during the 19 day gestation period.
Modulation
Modulation type CW
Additional info

Rectangular waveform.
Exposure setup
Exposure source
Chamber Anechoic room /2.55 m x 1.8 m x 2.9 m
Setup Animals were kept in round plastic cages (5 cm high, 23 cm diameter)
Additional info Cages were divided into 10 seperate boxes. Control anilmals were placed for the same period in identical cages.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4.23 mW/g mean calculated cf. remarks +/- 0.63 W/kg
power density 30 W/m² mean measured - time averaged in the center of the cage

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Overall no differences in body weight, mortality, organ weight and protein content of brain and liver were found between CW and AM exposed animals, respectivily, compared to control groups. The activity of aminoacyl tRNA synthetase isolated from brain of CW exposed animals was significantly decreased, whereas the enzym activity from liver was significantly increased in CW and AM exposed animals. No altered activity was found for the enzym isolated from brain of AM exposed animals.

Study character:

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