To study the effect of electromagnetic field exposure on the physiological behaviour of rat cortical synaptosomes by evaluating modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intra-synaptosomal mitochondrial Ca2+ concentration and free iron release.
12 experiments with synaptosomes of 12 male Sprague-Dawley rats were performed.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Modulation type:
pulsed
Exposure duration:
2 h
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 2 h |
| Modulation type | pulsed |
|---|---|
| Rise time | 2.7 ms |
| Fall time | 2.4 ms |
| Exposure source | |
|---|---|
| Setup | rectangular solenoid consisting of a coil with 2500 turns |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | peak value | measured | - | - |
The extremely low frequency magnetic field exposure did not affect the physiological behaviour of cortical synaptosomes: Oxygen consumption remained unvaried in exposed synaptosomes; ATP production was also unchanged. The intra-synaptosomal mitochondrial Ca2+ concentration decreased slowly and there was a slight, but non-significant depolarisation of the synaptosomal membrane potential. The free iron release remained unchanged after exposure.
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