To investigate whether magnetic field exposure is capable to influence the initiation event or the progress of tumor development in a rat liver model.
Male rats were subjected to a 70% partial hepatectomy. 24 h after hepatectomy 30mg/kg diethylnitrosamine (DENA) was injected intraperitoneal as a tumor initiator. One week later phenobarbital was given to promote growth of altered liver cells.
Rats were administered to a special diet, which did not induce the enzyme gamma-glutamyl transpeptidase.
Liver tissue slices were examined histopathologically for the presents of the enzymes gamma-glutamyl transpeptidase and glutathione S-transferase serving as markers for altered cell growth.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Modulation type:
CW
Exposure duration:
19 h/day, for 12 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Polarization | |
| Exposure duration | 19 h/day, for 12 weeks |
| Additional info | horizontal |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Chamber | polycarbonate plastic cages in exposure rack |
| Setup | equipment 114° to NS-axis |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 10 V/m | maximum | cf. remarks | - | induced |
| magnetic flux density | 500 µT | maximum | - | - | - |
| magnetic flux density | 50 µT | - | - | - | - |
| magnetic flux density | 5 µT | - | - | - | - |
| magnetic flux density | 0.5 µT | minimum | - | - | - |
Animals exposed to the magnetic fields exhibited a greater liver weight as unexposed controls. Partial hepatectomy followed by diethylnitrosamine-treatment produces pre-neoplastic liver lesions indicated by the expression of the above mentioned enzymes. No differences were found in relative liver weight and body weight gain between exposed animals and control groups. The number of histochemically stained enzyme-foci in the livers of the MF exposed groups were within the control range.
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