Medical/biological study (experimental study)

Low-frequency magnetic field effect on cytoskeleton and chromatin med./bio.

By: Kroupova J, Bartova E, Fojt L, Strasak L, Kozubek S, Vetterl V

Published in: Bioelectrochemistry 2007; 70 (1): 96-100

This study was performed to examine the effects of low frequency magnetic field on cytoskeleton and chromatin structure of human lung carcinoma cells in vitro.

Exposure	Parameters
Exposure 1: 50 Hz Exposure duration: continuous for 96 h	magnetic flux density: 2 mT mean

Exposure source	coil(s)
Setup	The Petri dishes (30 mm in diameter) were placed in the coil on a non-conducting stand where the field uniformity deviated about 3%. The control samples were kept under the same conditions without magnetic field.
Sham exposure	A sham exposure was conducted.

Measurand	Value	Type	Method	Mass	Remarks
magnetic flux density	2 mT	mean	unspecified	-	-

Exposed system:

Investigated system:

Time of investigation:

Slight morphological changes of F-actin filaments arrangement and mitochondria distribution were observed in magnetic field exposed cells and nuclear chromatin condensation was found. These changes were associated with apoptosis induced by the exposure to magentic field.
No statistically significant changes were found in the chromatin arrangement around the centromere.

Study character:

Wu X et al. (2018): Weak power frequency magnetic fields induce microtubule cytoskeleton reorganization depending on the epidermal growth factor receptor and the calcium related signaling
Wu X et al. (2014): Weak Power Frequency Magnetic Field Acting Similarly to EGF Stimulation, Induces Acute Activations of the EGFR Sensitive Actin Cytoskeleton Motility in Human Amniotic Cells
Fojt L et al. (2009): 50 Hz magnetic field effect on the morphology of bacteria
Sul AR et al. (2006): Effects of sinusoidal electromagnetic field on structure and function of different kinds of cell lines
Belyaev IY et al. (2005): 915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons
Bodega G et al. (2005): Acute and chronic effects of exposure to a 1-mT magnetic field on the cytoskeleton, stress proteins, and proliferation of astroglial cells in culture
Pirozzoli MC et al. (2003): Effects of 50 Hz electromagnetic field exposure on apoptosis and differentiation in a neuroblastoma cell line
Wei M et al. (2000): Exposure to 60 Hz magnetic fields and proliferation of human astrocytoma cells in vitro

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