Study type: Therapeutical study (experimental study)

Acquisition of ischemic tolerance by repetitive transcranial magnetic stimulation in the rat hippocampus med. app.

By: Ogiue-Ikeda M, Kawato S, Ueno S
Published in: Brain Res 2005; 1037 (1-2): 7-11
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Aim of study (acc. to author)

To study the ability of 0.75 T repetitive transcranial magnetic stimulation (rTMS) to protect the hippocampal function of the rat from ischemic injury.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Modulation type: pulsed
Exposure duration: repeated daily exposure, 4 times a day for 7 days (1000 pulses/day)

Exposure 1

Main characteristics
Frequency
Type
Waveform
Exposure duration repeated daily exposure, 4 times a day for 7 days (1000 pulses/day)
Additional info Frequency range not given.
Modulation
Modulation type pulsed
Additional info

The stimulator delivered biphasic cosine current pulses for 238 µs. Ten 1 sec trains of 25 pulses/s with 1 s interval were used.
Exposure setup
Exposure source
Setup Rats were magnetically stimulated using a round coil (15 mm inner diameter, 75 mm outer diameter, 10 mm thickness) positioned over the head. During the stimulation the rats were conscious and were held beneath the coil by the nape of the neck. Sham exposure was performed by treating the rats with a sham non-stimulated coil but exposed to the same noise as that produced during the stimulation.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 750 mT peak value unspecified - at the center of the coil
current density 9 A/m² maximum estimated - in the brain

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The long-term potentiation of the stimulated group was enhanced compared with the long-term potentiation of the sham control group in each ischemic condition, suggesting that repetitive transcranial magnetic stimulation has the potential to protect hippocampal function from ischemia.

Study character:

Study funded by

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