To study whether repetitive transcranial magnetic stimulation (rTMS) accelerates the onset of action and increases the therapeutic effects of amitriptyline in severe depressed patients.
Transcranial magnetic stimulation is a non-invasive method to stimulate the cortex, and the treatment of depression is one of its potential therapeutic applications.
The study comprised 46 outpatients with the diagnosis of non-psychotic major depressive disorder. All patients were concomitantly taking amitriptyline (mean dose 110 mg/d).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
5 Hz
Modulation type:
pulsed
Exposure duration:
intermittent, 25 trains per day, each train lasting 10 s with 20 s intervals - 5 sessions/week for 4 weeks
|
- |
| Frequency | 5 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | intermittent, 25 trains per day, each train lasting 10 s with 20 s intervals - 5 sessions/week for 4 weeks |
| Additional info | Transcranial magnetic stimulation (TMS) |
| Exposure source | |
|---|---|
| Setup | stimulation was carried out over the left dorsolateral prefrontal cortex |
| Sham exposure | A sham exposure was conducted. |
No parameters are specified for this exposure.
The study provides evidence that repetitive transcranial magnetic stimulation (rTMS) at 5 Hz is effective in accelerating and augmenting the therapeutic response to amitriptyline and it is safe and well-tolerated procedure.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.
