Epidemiological study (observational study)

Cellular telephone use and risk of acoustic neuroma epidem.

By: Christensen HC, Schüz J, Kosteljanetz M, Poulsen HS, Thomsen J, Johansen C

Published in: Am J Epidemiol 2004; 159 (3): 277-283

Aim of study (acc. to author)

The possible association between cellular telephone use and the risk of acoustic neuroma was investigated in this Danish nationwide population-based case-control study.

Further details

The study is part of the INTERPHONE project. Regular use of mobile phone was defined as more than one call per week for 6 months or more.

Endpoint/type of risk estimation

brain tumor: acoustic neuroma

Type of risk estimation:

incidence

(odds ratio (OR))

Exposure

- mobile communications
- mobile phone
- personal

Assessment

Type of assessment: Individual
interview: regular use, number of different cell phones, number of calls, use of handset and handsfree set
calculation: lifetime number of calls, lifetime number of hours of use

Exposure groups

Group	Description
Reference group 1	never used or less than once per week for six month
Group 2	use regularly
Group 3	time since first regular use never or rarely used < 1 year
Group 4	time since first regular use 1-4 year
Group 5	time since first regular use ≥ 5 year
Group 6	time since first regular use 5-9 year
Group 7	time since first regular use ≥ 10 year
Group 8	first telephone operating system: no information
Group 9	first telephone operating system: analogue
Group 10	first telephone operating system: digital
Group 11	lifetime cumulative number of calls ≤ 2975
Group 12	lifetime cumulative number of calls > 2975-11550
Group 13	lifetime cumulative number of calls > 11500
Group 14	lifetime cumulative hours of use ≤ 167.5
Group 15	lifetime cumulative hours of use > 167.5-654
Group 16	lifetime cumulative hours ofuse > 654
Group 17	cumulative use before diagnosis < 5 years
Group 18	cumulative use before diagnosis ≥ 5 years (≤ 81.7 hours)
Group 19	cumulative use before diagnosis ≥ 5 years (> 81.7 hours)

Population

Group:
- men
- women
Age: 20–69 years
Observation period: September 2000 - August 2002
Study location: Denmark

Case group

Characteristics: acoustic neuroma, primarily verified by magnetic resonance imaging
Data source: Department of Otolaryngology-Head and Neck Surgery, Gentofte Hospital, University of Copenhagen, Denmark
Exclusion criteria: deceased

Control group

Selection:
- population-based
Matching:
- sex
- age
- case:control = 1:2

Study size

	Cases	Controls
Eligible	141	332
Contacted	106	214
Participants	106	212

Statistical analysis method:

conditional logistic regression

(adjustment:

age
sex
residential area
education
marital status, use of hands-free device

)

Results (acc. to author)

The results showed no evidence for an association between cellular telephone use and the risk of acoustic neuroma.

Study funded by

Danish Cancer Society
European Union (EU)/European Commission
International Union against Cancer (UICC; Union Internationale Contre le Cancer), Switzerland

Comments on this article

Hardell L (2004): No association between mobile phone usage and development of acoustic neuroma
Savitz DA (2004): Mixed signals on cell phones and cancer
Hardell L et al. (2004): Re: "cellular telephone use and risk of acoustic neuroma"
Kundi M (2004): Re: "cellular telephone use and risk of acoustic neuroma"
Christensen HC et al. (2004): Re: "Cellular telephone use and risk of acoustic neuroma"

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