Study type: Medical/biological study (experimental study)

Permeability of the blood-brain barrier to mannitol in the rat following 2450 MHz microwave irradiation med./bio.

By: Preston E, Vavasour EJ, Assenheim HM
Published in: Brain Res 1979; 174 (1): 109-117
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Aim of study (acc. to author)

To determine if 2450 MHz continuous wave microwave energy increases blood-brain barrier permeability to [14C] mannitol .

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day for 8 days
Exposure 2: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day for 6 days

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Polarization
Exposure duration repeated daily exposure, 30 min/day for 8 days
Additional info vertiacally polarized electromagnetic field
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 m
Chamber anechoic chamber/8 m x 3 m x 3 m
Setup rat anesthetized with 60 mg/kg sodium pentobarbital was placed alone in prone position on a formed polyethylene support in the quiet zone of the chamber, facing the antenna.
Parameters
Measurand Value Type Method Mass Remarks
power density 1 W/m² mean measured - 0.5 mW/cm², 1 mW/cm², 5 mW/cm² and 10 mW/cm²
Additional parameter details

On the each experiment day, one rat (total of 8 rats) was exposed to each of the six different exposure fields (the sixth one being the sham exposure).

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Polarization
Exposure duration repeated daily exposure, 30 min/day for 6 days
Additional info horizontally polarized electromagnetic field
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 m
Chamber anechoic chamber/8 m x 3 m x 3 m, support array of acrylic and foamed polyethylen sheet
Setup window of animal cage, facing the horn antenna
Parameters
Measurand Value Type Method Mass Remarks
power density 3 W/m² mean measured - 1 mW/cm², 3 mW/cm², 10 mW/cm² and 30 mW/cm²
Additional parameter details

On each experimental day, one rat (total of 6 rats) was exposed to each of the six different exposure fields (the sixth one being sham exposure).

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Mean brain uptake index values for tissues from microwave-irradiated rats did not differ significantly from sham-irradiated animals, and a microwave influence on blood-brain barrier permeability was not evident.

Study character:

Study funded by