Study type: Medical/biological study (experimental study)

Effect of short electromagnetic pulses on brain acetylcholine content and spontaneous motor activity of mice med./bio.

By: Modak AT, Stavinoha WB, Deam AP
Published in: Bioelectromagnetics 1981; 2 (1): 89-92
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Aim of study (acc. to author)

To study the effect of short electromagnetic pulses on brain acetylcholine content and spontaneous motor activity of mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2,450 MHz
Modulation type: single pulse

Exposure 1

Main characteristics
Frequency 2,450 MHz
Type
Charakteristic
  • guided field
Additional info Stavinoha WB, Frazer J, Modak AT (1977): Microwave fixation for study of acetylcholine metabolism. In Jenden DJ (ed): "Cholinergic mechanisms and Psychopharmacology." New York: Plenum Press, pp 169-179.
Modulation
Modulation type single pulse
Additional info

pulse width of 15 or 25 ms
Exposure setup
Exposure source
Setup The microwave instrument described in [Stavinoha et al., 1977] was tuned for each mouse using an EH tuner, a milliwatt power source, and crystal receiver.
Sham exposure A sham exposure was conducted.
Additional info At various intervals after the pulse, some animals were killed by a second pulse of 250 ms duration.
Parameters
Measurand Value Type Method Mass Remarks
power 7.5 kW - - - -
Additional parameter details

Coupling efficiency between the 7.5-kW generator and the head was about 90%, and about 10% of the energy was deposited in the brain. A 25-ms pulse resulted in deposition of about 18.7 J in the brain.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Brain temperature was increased by 2°C in 15 ms and 4°C in 25 ms. Immediately after irradiation, the mice became hypokinetic but began recovering within 5 minutes. The 25 ms pulse caused a significant decrease in acetylcholine content of the whole brain, probably owing to increased permeability of the membrane.

Study character:

Study funded by

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