Study type: Medical/biological study (experimental study)

Effect of a 9 mT pulsed magnetic field on C3H/Bi female mice with mammary carcinoma. A comparison between the 12 Hz and the 460 Hz frequencies med./bio.

By: Bellossi A, Desplaces A
Published in: In Vivo 1991; 5 (1): 39-40
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Aim of study (acc. to author)

In this study the effects of a pulsed magnetic field on the lifespan, tumor weight, spleen weight, and lung weight on female mice were examined and compared with a previous study at 460 Hz (Bellossi 1988, q.v. publication 1372).

Background/further details

The mice develop spontaneous viral mammary carcinoma which can metastasize to the lungs. 79 mice were used in this study (52 exposed/27 control). Exposure was initiated 2-3 weeks after spontanous tumor appeared.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 12 Hz
Modulation type: pulsed
Exposure duration: 10 min, 3 non-consecutive days/week from 2-3 weeks after appearance of the tumor until death of the animal
Exposure 2: 460 Hz
Modulation type: pulsed
Exposure duration: 10 min, 3 non-consecutive days/week from 2-3 weeks after appearance of the tumor until death of the animal

Exposure 1

Main characteristics
Frequency 12 Hz
Type
Waveform
Exposure duration 10 min, 3 non-consecutive days/week from 2-3 weeks after appearance of the tumor until death of the animal
Modulation
Modulation type pulsed
Exposure setup
Exposure source
  • 2 Magnobiopulse applicators with 12 cm diameter each on top of the container with the mice
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 9 mT - - - -

Exposure 2

Main characteristics
Frequency 460 Hz
Type
Waveform
Exposure duration 10 min, 3 non-consecutive days/week from 2-3 weeks after appearance of the tumor until death of the animal
Modulation
Modulation type pulsed
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 9 mT - - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No effects were observed on mean survival time, tumor, spleen, and lung weight. Comparison with earlier findings at 460 Hz showed no significant differences.

Study character:

Study funded by

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