Study type: Medical/biological study (experimental study)

Tolazoline decreases survival time during microwave-induced lethal heat stress in anesthetized rats med./bio.

By: Jauchem JR, Chang KS, Frei MR
Published in: Proc Soc Exp Biol Med 1996; 211 (3): 236-243
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Aim of study (acc. to author)

To examine effects of tolazoline (10 mg/kg body weight) on heart rate, mean arterial blood pressure, respiratory rate, localized body temperature changes, survival times, and lethal body temperatures that occur during exposure of anesthetized rats to 2450 MHz microwave radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: until death of the animal

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Exposure duration until death of the animal
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.15 m
Setup long axis of the animal body parallel to the magnetic field
Parameters
Measurand Value Type Method Mass Remarks
SAR 14 W/kg - calculated whole body -
power density 60 mW/cm² spatial average - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

Survival time was significantly shorter in the tolazoline group than in saline-treated control animals. Heart rate and blood pressure responses were similar to those that occur during environmental heat stress. Heart rate, however, was significantly elevated in animals that received tolazoline. It is possible that changes associated with the elevated heart rate in tolazoline-treated animals resulted in greater susceptibility to microwave-induced heating and the lower survival time.

Study character:

Study funded by