To determine if chlorpromazine affects the thermal responses, heart rate, blood pressure, and respiratory rate of anesthetized rats during exposure to 5.6 GHz radiofrequency irradiation (this frequency is characteristic of high-power stationary tracking radars for military applications and of naval ship radars).
Experiments were performed that resulted in two stages: 1) exposures were performed that resulted in colonic temperture increase from 38.5 to 39.5°C, and 2) radiofrequency irradiation was initiated at 38.5°C and continued until death body temperatures were attained.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
5.6 GHz
Modulation type:
CW
Exposure duration:
until temperature rise of 1°C
|
|
|
Exposure 2:
5.6 GHz
Modulation type:
CW
|
|
| Frequency | 5.6 GHz |
|---|---|
| Type | |
| Charakteristic | |
| Exposure duration | until temperature rise of 1°C |
| Additional info | exposure started at a colonic temperature of 38.5°C; exposure was discontinued when the colonic temperature increased to 39.5°C and it was initiated again when the temperature returned to 38.5°C; this procedure was continued for 6 cycles (drugs were administered before the 4th cycle). |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Setup | long axis of animal parallel to the magnetic field |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 60 mW/cm² | average over time | measured | - | - |
| SAR | 12 W/kg | average over time | calculated | whole body | - |
| Modulation type | CW |
|---|
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 60 mW/cm² | average over time | measured | - | - |
| SAR | 12 W/kg | average over mass | calculated | whole body | - |
After acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when irradiation was discontinued. When irradiation was initiated at 38.5°C and continued until lethal temperatures resulted, chlorpromazine-treated rats exhibited significantly shorter survival times than saline-treated rats. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperatures below 39.5°C, the drug produced increased susceptibility to terminal radiofrequency irradiation.
The present findings, when compared to previous studies of irradiation at 2.8 GHz (e.g. publication 4486), suggest that the effects of chlorpromazine on thermal responses to radiofrequency irradiation during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.
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