Study type: Medical/biological study (experimental study)

Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo med./bio.

By: Ushiyama A, Masuda H, Hirota S, Wake K, Kawai H, Watanabe S, Taki M, Ohkubo C
Published in: Environmentalist 2007; 27 (4): 489-492
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Aim of study (acc. to author)

This study was conducted to examine the radio frequency effect on the blood-cerebrospinal fluid barrier permeability in rats.

Background/further details

The blood-cerebrospinal fluid barrier is a physiological barrier between blood circulation and cerebrospinal fluid system in brain with a complete permeability only for water and water soluable gases.
A cannula was implanted into lateral brain ventricle of both juvenile and adult male rats to gain cerebrospinal fluid. After FITC-albumin injection into caudal vein fluorescence intensity of FITC-albumin was measured in cerebrospinal fluid for 180 minutes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1.5 GHz
Modulation type: pulsed
Exposure duration: continuous for 30 min
  • SAR: 0.5 W/kg average over mass (brain)
  • SAR: 2 W/kg average over mass (brain)
  • SAR: 9.5 W/kg average over mass (brain)
Exposure 2: 1.5 GHz
Modulation type: pulsed
Exposure duration: continuous for 30 min
  • SAR: 0.6 W/kg average over mass (brain)
  • SAR: 2.2 W/kg average over mass (brain)
  • SAR: 10.4 W/kg average over mass (brain)

Exposure 1

Main characteristics
Frequency 1.5 GHz
Type
Charakteristic
Exposure duration continuous for 30 min
Additional info adult rats
Modulation
Modulation type pulsed
Additional info

TDMA signal for Japanese PDC systems
Exposure setup
Exposure source
Setup The rat's head was locally exposed by the antenna placed 5 mm upward to the parietal region.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.5 W/kg average over mass - brain -
SAR 2 W/kg average over mass - brain -
SAR 9.5 W/kg average over mass - brain -

Exposure 2

Main characteristics
Frequency 1.5 GHz
Type
Charakteristic
Exposure duration continuous for 30 min
Additional info juvenile rats
Modulation
Modulation type pulsed
Additional info

TDMA signal for Japanese PDC systems
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.6 W/kg average over mass - brain -
SAR 2.2 W/kg average over mass - brain -
SAR 10.4 W/kg average over mass - brain -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No statistically significant effects of radio frequency exposure on blood-cerebrospinal fluid barrier permeability in rats were observed.

Study character:

Study funded by

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