In order to explore the possible effects of millimeter waves on gap junction intercellular communication and compare this with extremely low frequency (ELF), gap junction intercellular communication in HaCaT cells exposed to 30.16 GHz millimeter waves was analyzed, both in the presence and in the absence of TPA (12-O-tetradecanoylphorbol-13-acetate).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
30.16 GHz
Modulation type:
CW
Exposure duration:
continuous for 1 h
|
|
Six groups were used in the study: 1) control 0 mW/cm², no TPA treatment; 2) 1.0 mW/cm² MMW exposure group 3) 3.5 mW/cm² MMW exposure group; 4)1.0 mW/cm² MMW exposure group + TPA; 5) 3.5 mW/cm² MMW + TPA; 6) TPA
| Frequency | 30.16 GHz |
|---|---|
| Exposure duration | continuous for 1 h |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Chamber | Exposure chamber with 2 mm thick aluminum sheet/ 15 cm x 11 cm x 7 cm |
| Setup | 30 mm diameter dish containing the cell culture was placed at the top of the horn antenna. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 3.5 mW/cm² | maximum | measured | - | min value: 1.0 mW/cm² |
Millimeter wave exposure alone for 1 h (1.0 or 3.5 mW/cm²) did not affect gap junction intercellular communication. Millimeter wave exposure in combination with TPA treatment (5 ng/ml) reversed TPA induced suppression of gap junction intercellular communication. Radiation at 1.0 mW/cm² resulted in a partial reversal, and exposure at 3.5 mW/cm² resulted in essentially full reversal of the TPA suppression.
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